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Monthly QUIZ 

June 2003

Designed by;

O. Zargari , MD

Razi Hospital, Rasht, Iran

A 3-year-old boy presented with a few weeks history for a pruritic vesiculobullous eruptions on his face, lower trunk and extremities....

 What's your diagnosis?

Dx: Chronic Bullous Disorder of Childhood (CBDC)

CBDC is a blistering disease characterized by large, tense, and clustered subepidermal bullae. The lesions are distributed mainly on the lower part of the trunk, pelvic region, groins, and lower extremities. Presence of annular and serpiginous erythematous patches with bullae arranged at the periphery of the patches is a typical feature in CBDC.

The immunologic hallmark of the disease is linear IgA deposits at the basement membrane zone.

Dapsone or sulphapyridine usually control the eruption rapidly and spontaneous remission seems to occur in the majority of the cases after an average of 3-4 years.